Complete publication list

研究論文

2021

  • Fukumura K, Yoshimoto R, Sperotto L, Kang HS, Hirose T, Inoue K, Sattler M, Mayeda A. SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns. Nat Commun. 12(1): 4910.
  • Yamazaki T, Hirose T. Control of condensates dictates nucleolar architecture. Science. 373(6554): 486-487.
  • Ninomiya K, Iwakiri J, Aly MK, Sakaguchi Y, Adachi S, Natsume T, Terai G, Asai K, Suzuki T, Hirose T. m6A modification of HSATIII lncRNAs regulates temperature-dependent splicing. EMBO J. 40(15) e107976.
  • Nakagawa S, Yamazaki T, Mannen T, Hirose T. ArcRNAs and the formation of nuclear bodies. Mamm genome. doi: 10.1007/s00335-021-09881-5
  • Yamazaki T, Yamamoto T, Yoshino H, Souquere S, Nakagawa S, Pierron G, Hirose T. Paraspeckles are constructed as block copolymer micelles. EMBO J. 40(12) e107270.
  • Shibata T, Nagano K, Ueyama M, Ninomiya K, Hirose T, Nagai Y, Ishikawa K, Kawai G, Nakatani K. Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model. Nat Commun. 12(1): 236–236.
  • Yamazaki T, Hirose T. CRISPR-Mediated Mutagenesis of Long Noncoding RNAs. Methods Mol Biol. 2254: 283–303.

2020

  • Gidlöf O, Bader K, Celik S, Grossi M, Nakagawa S, Hirose T, Metzler B, Olde B, Erlinge D. Inhibition of the long non-coding RNA NEAT1 protects cardiomyocytes from hypoxia in vitro via decreased pri-miRNA processing. Cell Death Dis. 11(8). 677.
  • Ramilowski JA, Yip CW, Agrawal S, Chang JC, Ciani Y, Kulakovskiy IV, Mendez M, Ooi JLC, Ouyang JF, Parkinson N, Petri A, Roos L, Severin J, Yasuzawa K, Abugessaisa I, Akalin A, Antonov IV, Arner E, Bonetti A, Bono H, Borsari B, Brombacher F, Cameron CJ, Cannistraci CV, Cardenas R, Cardon M, Chang H, Dostie J, Ducoli L, Favorov A, Fort A, Garrido D, Gil N, Gimenez J, Guler R, Handoko L, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto K, Hayatsu N, Heutink P, Hirose T, Imada EL, Itoh M, Kaczkowski B, Kanhere A, Kawabata E, Kawaji H, Kawashima T, Kelly ST, Kojima M, Kondo N, Koseki H, Kouno T, Kratz A, Kurowska-Stolarska M, Kwon ATJ, Leek J, Lennartsson A, Lizio M, López-Redondo F, Luginbühl J, Maeda S, Makeev VJ, Marchionni L, Medvedeva YA, Minoda A, Müller F, Muñoz-Aguirre M, Murata M, Nishiyori H, Nitta KR, Noguchi S, Noro Y, Nurtdinov R, Okazaki Y, Orlando V, Paquette D, Parr CJC, Rackham OJL, Rizzu P, Sánchez Martinez DF, Sandelin A, Sanjana P, Semple CAM, Shibayama Y, Sivaraman DM, Suzuki T, Szumowski SC, Tagami M, Taylor MS, Terao C, Thodberg M, Thongjuea S, Tripathi V, Ulitsky I, Verardo R, Vorontsov IE, Yamamoto C, Young RS, Baillie JK, Forrest ARR, Guigó R, Hoffman MM, Hon CC, Kasukawa T, Kauppinen S, Kere J, Lenhard B, Schneider C, Suzuki H, Yagi K, de Hoon MJL, Shin JW, Carninci P. Functional annotation of human long noncoding RNAs via molecular phenotyping. Genome Res. 30(7): 1060–1072.
  • Kukharsky MS, Ninkina NN, An H, Telezhkin V, Wei W, Meritens CR, Cooper-Knock J, Nakagawa S, Hirose T, Buchman VL, Shelkovnikova TA. Long non-coding RNA Neat1 regulates adaptive behavioural response to stress in mice. Transl Psychiatry. 10(1): 171–171.
  • Isobe M, Toya H, Mito M, Chiba T, Asahara H, Hirose T, Nakagawa S. Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice. RNA. 26(3): 251-264.
  • Ninomiya K, Hirose T. Short Tandem Repeat-Enriched Architectural RNAs in Nuclear Bodies: Functions and Associated Diseases. Non-coding RNA. 6(1).
  • Yamazaki T, Nakagawa S, Hirose T. Architectural RNAs for Membraneless Nuclear Body Formation. Cold Spring Harb Symp Quant Biol. 84: 227-237.
  • Ninomiya K, Adachi S, Natsume T, Iwakiri J, Terai G, Asai K, Hirose T. LncRNA-dependent nuclear stress bodies promote intron retention through SR protein phosphorylation. EMBO J. 39(3): e102729.
  • Liang S, Takahashi H, Hirose T, Kuramitsu Y, Hatakeyama S, Yoshiyama H, Wang R, Hamada J, Iizasa H. NONO Is a Negative Regulator of SOX2 Promoter. Cancer Genomics Proteomics. 17(4): 359–367.
  • Yamamoto T, Yamazaki T, Hirose T. Phase separation driven by production of architectural RNA transcripts. Soft Matter. 16(19): 4692–4698.

2019

  • Adriaens C, Rambow F, Bervoets G, Silla T, Mito M, Chiba T, Asahara H, Hirose T, Nakagawa S, Jensen TH, Marine JC. The long noncoding RNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth. RNA. 25(12): 1681-1695.
  • Gast M, Rauch B, Haghikia A, Nakagawa S, Haas J, Stroux A, Schmidt D, Schumann P, Weiss S, Jensen L, Kratzer A, Kraenkel N, Müller C, Börnigen D, Hirose T, Blankenberg S, Escher F, Kühl A, Kuss A, Meder B, Landmesser U, Zeller T, Poller W. Long noncoding RNA NEAT1 modulates immune cell functions and is suppressed in early onset myocardial infarction patients. Cardiovasc Res. 115(13): 1886-1906.
  • Hirose T, Yamazaki T, Nakagawa S. Molecular anatomy of the architectural NEAT1 noncoding RNA: the domains, interactors, and biogenesis pathway required to build phase-separated nuclear paraspeckles. Wiley Interdiscip Rev RNA. 10(6): e1545.
  • Aly MK, Ninomiya K, Adachi S, Natsume T, Hirose T. Two distinct nuclear stress bodies containing different sets of RNA-binding proteins are formed with HSATIII architectural noncoding RNAs upon thermal stress exposure. Biochem Biophys Res Commun. 516(2): 419-423.
  • Modic M, Grosch M, Rot G, Engert S, Lepko T, Yamazaki T, Lee FCY, Rusha E, Shaposhnikov D, Palo M, Merl-Pham J, Cacchiarelli D, Rogelj B, Hauck SM, von Mering C, Meissner A, Lickert H, Hirose T, Ule J, Drukker M. Cross-regulation between TDP-43 and paraspeckles promotes pluripotency differentiation transition. Mol Cell. 74(5): 951-965.e13.
  • Katsel P, Roussos P, Fam P, Khan S, Tan W, Hirose T, Nakagawa S, Pletnikov MV, Haroutunian V. The expression of long noncoding RNA NEAT1 is reduced in schizophrenia and modulates oligodendrocytes transcription. NPJ Schizophr. 5(1): 3.

2018

  • Nakagawa S, Yamazaki T, Hirose T. Molecular dissection of nuclear paraspeckles: towards understanding the emerging world of the RNP milieu. Open Biol. 8(10) 180150.
  • Yamazaki T, Fujikawa C, Kubota A, Takahashi A, Hirose T. CRISPRa-mediated NEAT1 lncRNA upregulation induces formation of intact paraspeckles. Biochem Biophys Res Commun. 504(1): 218-224.
  • Ahmed ASI, Dong K, Liu J, Wen T, Yu L, Xu F, Kang X, Osman I, Hu G, Bunting KM, Crethers D, Gao H, Zhang W, Liu Y, Wen K, Agarwal G, Hirose T, Nakagawa S, Vazdarjanova A, Zhou J. Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells. Proc Natl Acad Sci USA. 115(37): E8660-E8667.
  • Yamazaki T, Souquere S, Chujo T, Kobelke S, Chong YS, Fox AH, Bond CS, Nakagawa S, Pierron G, Hirose T. Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation. Mol Cell. 70(6): 1038-1053.e7.
  • Fox AH, Nakagawa S, Hirose T, Bond CS. Paraspeckles: Where Long Noncoding RNA Meets Phase Separation. Trends Biochem Sci. 43(2): 124-135.

2017

  • Chujo T, Hirose T. Nuclear bodies built on architectural long noncoding RNAs: unifying principles of their construction and function. Mol Cells. 40(12): 889-896.
  • Mello SS, Sinow C, Raj N, Mazur PK, Bieging-Rolett K, Broz DK, Imam JFC, Vogel H, Wood LD, Sage J, Hirose T, Nakagawa S, Rinn J, Attardi LD. Neat1 is a p53-inducible lincRNA essential for transformation suppression. Genes Dev. 31(11): 1095-1108.
  • Chujo T, Yamazaki T, Kawaguchi T, Kurosaka S, Takumi T, Nakagawa S, Hirose T. Unusual semi-extractability as a hallmark of nuclear body-associated architectural noncoding RNAs. EMBO J. 36(10): 1447-1462.
  • Mannen T, Hirose T. RNase sensitivity screening for nuclear bodies with RNA scaffolds in mammalian cells. Bio-protocol. 7.

2016

  • Anantharaman A, Jadaliha M, Tripathi V, Nakagawa S, Hirose T, Jantsch MF, Prasanth SG, Prasanth KV. Paraspeckles modulate the intranuclear distribution of paraspeckle-associated Ctn RNA. Sci Rep. 6: 34043.
  • West JA, Mito M, Kurosaka S, Takumi T, Tanegashima C, Chujo T, Yanaka K, Kingston RE, Hirose T, Bond C, Fox A, Nakagawa S. Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization. J Cell Biol. 214(7): 817-30.
  • Aly, MK, Hirose T. GAS5 Gene. In: eLS. John Wiley & Sons Ltd, Chichester.
  • Yamamoto K, Furukawa M, Fukumura K, Kawamura A, Yamada T, Suzuki H, Hirose T, Sakamoto H, Inoue K. Control of the heat stress-induced alternative splicing of a subset of genes by hnRNP K. Genes Cells. 21(9): 1006-14.
  • Mannen T, Yamashita S, Tomita K, Goshima N, Hirose T. The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL. J Cell Biol. 214(1): 45-59.
  • Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, Boeckx B, Wijnhoven PWG, Radaelli E, Vermi W, Leucci E, Lapouge G, Beck B, ven den Oord J, Nakagawa S, Hirose T, Sablina AA, Lambrechts D, Aerts S, Blanpain C, Marine JC. p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat. Med. 22(8): 861-8.
  • Hirose T, Nakagawa S. Clues to long noncoding RNA taxonomy. Biochim Biophys Acta. 1859(1): 1-2.
  • Chujo T, Yamazaki T, Hirose T. Architectural RNAs (arcRNAs): A class of long noncoding RNAs that function as the scaffold of nuclear bodies. Biochim Biophys Acta. 1859(1): 139-46.
  • Mito M, Kawaguchi T, Hirose T, Nakagawa S. Simultaneous multicolor detection of RNA and proteins using super-resolution microscopy. Methods. 98: 158-65.

2015

  • Kawaguchi T, Hirose T. Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies. Nucleus. 6(6): 462-7.
  • Hennig S, Kong G, Mannen T, Sadowska A, Kobelke S, Blythe A, Knott GJ, Iyer KS, Ho D, Newcombe EA, Hosoki K, Goshima N, Kawaguchi T, Hatters D, Trinkle-Mulcahy L, Hirose T*, Bond CS*, Fox AH*. Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles. J Cell Biol. 210(4): 529-39. (* equally contributed)
  • Kawaguchi T, Tanigawa A, Naganuma T, Ohkawa Y, Souquere S, Pierron G, Hirose T. SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies. Proc Natl Acad Sci U S A. 112(14): 4304-9.
  • *Mannen T, *Chujo T, Hirose T. Long noncoding RNAs as structural and functional components of nuclear bodies. Long Noncoding RNAs: Structures and Functions.ed. Kurokawa. R.Springer.111-132. (* equally contributed)
  • Yamazaki T, Hirose T. The building process of the functional paraspeckle with long non-coding RNAs. Front Biosci (Elite Ed). 7: 1-41.
  • Hirose T, Goshima N. Genome-wide co-localization screening of nuclear body components using a fluorescently tagged FLJ cDNA clone library. Methods Mol Biol. 1262: 155-63.
  • Hirose T, Mannen T. Rapid and efficient elimination of specific nuclear noncoding RNAs in mammalian cells with antisense oligonucleotides. Methods Mol Biol. 1206: 149-56.

2014

  • Nakagawa S, Shimada M, Yanaka K, Mito M, Arai T, Takahashi E, Fujita Y, Fujimori T, Standaert L, Marine JC, Hirose T. The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice. Development. 141(23): 4618-27.
  • Standaert L, Adriaens C, Radaelli E, Van Keymeulen A, Blanpain C, Hirose T, Nakagawa S, Marine JC. The long noncoding RNA Neat1 is required for mammary gland development and lactation. RNA. 20(12): 1844-9.
  • Chakravarty D, Sboner A, Nair SS, Giannopoulou E, Li R, Hennig S, Mosquera JM, Pauwels J, Park K, Kossai M, MacDonald TY, Fontugne J, Erho N, Vergara IA, Ghadessi M, Davicioni E, Jenkins RB, Palanisamy N, Chen Z, Nakagawa S, Hirose T, Bander NH, Beltran H, Fox AH, Elemento O, Rubin MA. The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nat. Commun. 5: 5383.
  • Hirose T, Mishima Y, Tomari Y. Elements and machinery of non-coding RNAs: toward their taxonomy. EMBO Rep. 15(5): 489-507.
  • Ono H, Motoi N, Nagano H, Miyauchi E, Ushijima M, Matsuura M, Okumura S, Nishio M, Hirose T, Inase N, Ishikawa Y. Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer. Cancer Med. 3(3): 632-42.
  • Hirose T*, Virnicchi G, Tanigawa A, Naganuma T, Li R, Kimura H, Yokoi T, Nakagawa S, Benard M, Fox A*, Pierron G*. NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies. Mol Biol Cell. 25(1): 169-83. (*co-corresponding).

2013

  • Nishimoto Y, Nakagawa S, Hirose T, Okano HJ, Takao M, Shibata S, Suyama S, Kuwako K, Imai T, Murayama S, Suzuki N, Okano H. The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis. Mol Brain. 6: 31.
  • Naganuma T, Hirose T. Paraspeckle formation during the biogenesis of long non-coding RNAs. RNA Biol. 10(3): 456-61.

2012

  • Naganuma T, Nakagawa S, Tanigawa A, Sasaki YF, Goshima N, Hirose T. Alternative 3′-end processing of long noncoding RNA initiates construction of nuclear paraspeckles. EMBO J. 31(20): 4020-34.
  • Ideue T, Adachi S, Naganuma T, Tanigawa A, Natsume T, Hirose T. U7 small nuclear ribonucleoprotein represses histone gene transcription in cell cycle-arrested cells. Proc Natl Acad Sci U S A. 109(15): 5693-8.
  • Nakagawa S, Ip JY, Shioi G, Tripathi V, Zong X, Hirose T, Prasanth KV. Malat1 is not an essential component of nuclear speckles in mice. RNA. 18(8): 1487-99.
  • Hirose T, Nakagawa S. Paraspeckles: possible nuclear hubs by the RNA for the RNA. Biomol Concepts. 3(5): 415-28.
  • Nakagawa S, Hirose T. Paraspeckle nuclear bodies–useful uselessness? Cell Mol Life Sci. 69(18): 3027-36.
  • Kawaguchi T, Hirose T. Architectural roles of long noncoding RNAs in the intranuclear formation of functional paraspeckles. Front Biosci (Landmark Ed). 17: 1729-46.
  • Miyagawa R, Mizuno R, Nakamura Y, Ijiri K, Rakwal R, Shibato J, Masuo Y, Hirose T, Akimitsu N. Identification of the cis-acting and trans-acting determinants of noncoding RNA MALAT-1 for the nuclear speckles localization. RNA. 18(4): 738-51.

2011

  • Nakagawa S, Naganuma T, Shioi G, Hirose T. Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice. J Cell Biol. 193(1): 31-9.
  • Hirose T. Gas5 gene. version 2. Encyclopedia on Human Genome. e1-5.

2010

  • Aoki K, Harashima A, Sano M, Yokoi T, Nakamura S, Kibata M, Hirose T. A thymus-specific noncoding RNA, Thy-ncR1, is a cytoplasmic riboregulator of MFAP4 mRNA in immature T-cell lines. BMC Mol Biol. 11: 99.
  • Hirose T. Emerging roles of noncoding RNAs in subcellular architecture and gene expression. RNA technologies & Their applications. : 370-386 Springer.

2009

  • Sasaki YT, Ideue T, Sano M, Mituyama T, Hirose T. MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles. Proc Natl Acad Sci U S A. 106(8): 2525-30.
  • Ideue T, Hino K, Kitao S, Yokoi T, Hirose T. Efficient oligonucleotide-mediated degradation of nuclear noncoding RNAs in mammalian cultured cells. RNA. 15(8): 1578-87.
  • Kikuchi K, Fukuda M, Ito T, Inoue M, Yokoi T, Chiku S, Mitsuyama T, Asai K, Hirose T, Aizawa Y. Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. Nucleic Acids Res. 37(15): 4987-5000.
  • Sasaki YT, Hirose T. How to build a paraspeckle. Genome Biol. 10(7): 227.

2007

  • Ideue T, Sasaki YT, Hagiwara M, Hirose T. Introns play an essential role in splicing-dependent formation of the exon junction complex. Genes Dev. 21(16): 1993-8.
  • Fukumura K, Kato A, Jin Y, Ideue T, Hirose T, Kataoka N, Fujiwara T, Sakamoto H, Inoue K. Tissue-specific splicing regulator Fox-1 induces exon skipping by interfering E complex formation on the downstream intron of human F1gamma gene. Nucleic Acids Res. 35(16): 5303-11.
  • Nojima T, Hirose T, Kimura H, Hagiwara M. The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export. J Biol Chem. 282(21): 15645-51.
  • Sasaki YT, Sano M, Ideue T, Kin T, Asai K, Hirose T. Identification and characterization of human non-coding RNAs with tissue-specific expression. Biochem Biophys Res Commun. 357(4): 991-6.
  • Sasaki YT, Sano M, Kin T, Asai K, Hirose T. Coordinated expression of ncRNAs and HOX mRNAs in the human HOXA locus. Biochem Biophys Res Commun. 357(3): 724-30.
  • Kuroda H, Suzuki H, Kusumegi T, Hirose T, Yukawa Y, Sugiura M. Translation of psbC mRNAs starts from the downstream GUG, not the upstream AUG, and requires the extended Shine-Dalgarno sequence in tobacco chloroplasts. Plant Cell Physiol. 48(9): 1374-8.

2006

  • Hirose T*, Ideue T, Nagai M, Hagiwara M, Shu M-D, Steitz JA*. A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing. Mol Cell. 23(5): 673-84. (*co-corresponding).

2004

  • Hirose T, Shu MD, Steitz JA. Splicing of U12-type introns deposits an exon junction complex competent to induce nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 101(52): 17976-81.
  • Hirose T, Sugiura M. Multiple elements required for translation of plastid atpB mRNA lacking the Shine-Dalgarno sequence. Nucleic Acids Res. 32(11): 3503-10.
  • Hirose T, Sugiura M. Functional Shine-Dalgarno-like sequences for translational initiation of chloroplast mRNAs. Plant Cell Physiol. 45(1): 114-7.
  • Hirose T, Miyamoto T, Obokata J, Sugiura M. In vitro RNA editing systems from higher plant chloroplasts. Methods Mol Biol. 265: 333-44.

Before 2003

  • Hirose T, Shu M-D, Steitz JA. Splicing-dependent and independent modes of assembly for intron-encoded box C/D snoRNPs in mammalian cells. Mol. Cell. 12: 113-123, 2003.
  • Hirose T, Steitz JA. gas5 gene. (Level 3 article). Encyclopedia on Human Genome. Nature Publishing group, 2003.
  • Hirose T, Steitz JA. Positions within host intron is critical for efficient processing of box C/D snoRNAs in mammalian cell. Proc. Natl. Acad. Sci. USA. 98: 12914-12919, 2001.
  • Hirose T, Sugiura M. Involvement of a site-specific trans-acting factor and a common RNA-binding protein in the editing of chloroplast mRNAs: development of a chloroplast in vitro RNA editing system. EMBO J. 20: 1144-1152, 2001.
  • Hirose T, Kusumegi T, Tsudzuki T, Sugiura M. RNA editing sites in tobacco chloroplast transcripts: editing as a possible regulator of chloroplast RNA polymerase activity. Mol. Gen. Genet. 262: 462-467, 1999.
  • Hirose T, Ideue T, Wakasugi T, Sugiura M. The chloroplast infA gene with a functional UUG initiation codon. FEBS Lett. 445: 169-172, 1999.
  • Hirose T, Kusumegi T, Sugiura M. Translation of tobacco chloroplast rps14 mRNA depends on a Shine-Dalgarno-like sequence in the 5′-untranslated region but not on internal RNA editing in the coding region. FEBS Lett. 430: 257-60, 1998.
  • Sugiura M, Hirose T, Sugita M. Evolution and mechanism of translation in chloroplasts. Annu. Rev. Genet. 32:437-459, 1998.
  • Sugiura M, Kusumegi T, Sugishita H, Murakami K, Ideue T, Hirose T. Translational control of photosynthetic genes in tobacco plastids. Photosynthesis: Mechanisms and Effects IV. : 2943-2946, 1998.
  • Mutsuda M, Hirose T, Sugiura M, Sugita M. The function of the cyanobacterial RNA-binding proteins. Photosynthesis: Mechanisms and Effects IV. : 2937-2940, 1998.
  • Tsudzuki T, Tsuduzki J, Nakashima K, Wakasugi T, Hirose T, Sugita M, Sugiura M. Newly identified genes in tobacco plastid genome. Photosynthesis: Mechanisms and Effects IV. : 2953-2956, 1998.
  • Hirose T, Sugiura M. Both RNA editing and RNA cleavage are required for translation of tobacco chloroplast ndhD mRNA : a possible regulatory mechanism for the expression of a chloroplast operon consisting of functionally unrelated gene. EMBO J. 16: 6804-6811, 1997.
  • Hirose T, Sugiura M. Cis-acting elements and trans-acting factor(s) for accurate translation of tobacco psbA mRNA in chloroplasts; development of a chloroplast in vitro translation system. EMBO J. 15: 1687-1695, 1996.
  • Wakasugi T, Hirose T, Horihata M, Tsudzuki T, Kossel H, Sugiura M. Creation of a novel protein-coding region at the RNA level in black pine chloroplasts: the pattern of RNA editing in the gymnosperm chloroplast is different from that in angiosperms. Proc. Natl. Acad. Sci. USA. 93: 8766-8770, 1996.
  • Vera A, Hirose T, Sugiura M. A ribosomal protein gene (rpl32) from tobacco chloroplast DNA is transcribed from alternative promoters: similarities in promoter region organization in plastid housekeeping genes. Mol. Gen. Genet. 251: 518-525, 1996.
  • Hirose T, Fan H, Suzuki JY, Wakasugi T, Tsudzuki T, Kossel H, Sugiura M. Occurrence of silent RNA editing in chloroplasts: its species specificity and the influence of environmental and developmental conditions. Plant Mol. Biol. 30: 667-672, 1996.
  • Hirose T, Sugita M, Sugiura M. In vivo and in vitro analysis of translation of psbA transcripts in tobacco chloroplasts. Photosynthesis: Mechanisms and Effects III. : 695-698, 1995.
  • Tsuzduki T, Hirose T, Fan H, Suzuki JY, Wakasugi T, Kossel H, Sugiura M. RNA editing in atpA and atpF transcripts from tobacco. Photosynthesis: Mechanisms and Effects III. : 687-690, 1995.
  • Hirose T, Wakasugi T, Sugiura M, Kossel H. RNA editing of tobacco petB mRNAs occurs both in chloroplasts and non-photosynthetic proplastids. Plant Mol. Biol. 26: 509-513, 1994.
  • Hirose T, Sugita M, Sugiura M. Characterization of a cDNA encoding a novel type of RNA-binding protein in tobacco: its expression and nucleic acid-binding properties. Mol. Gen. Genet. 244: 360-366, 1994.
  • Yokoyama R, Hirose T, Fujii N, Aspuria ET, Kato A, Uchimiya H. The rolC promoter of Agrobacterium rhizogenes Ri plasmid is activated by sucrose in transgenic tobacco plants. Mol. Gen. Genet. 244: 15-22, 1994.
  • Hirose T, Sugita M, Sugiura M. cDNA structure, expression and nucleic acid-binding properties of three RNA-binding proteins in tobacco. Nucleic Acids Res. 21: 3981-3987, 1993.

 

和文総説等

2021年

  • 廣瀬哲郎 概論:相分離研究による細胞像の再構築、実験医学増刊(相分離:メカニズムと疾患39(10): 1466
  • 山崎智弘、山本哲也、廣瀬哲郎 パラスペックル、実験医学増刊(相分離:メカニズムと疾患39(10): 1520-1526
  • 山崎智弘、廣瀬哲郎 RNAが形作る相分離構造体、生化学 93(3): 385-390

2020年

  • 山崎智弘、廣瀬哲郎 核内の相分離、相分離生物学の全貌(現代科学増増刊46): 15-18
  • 廣瀬哲郎 ゲノムの暗黒物質はどこまで解明されたか、北海道医学雑誌 95(2):99-101
  • 廣瀬哲郎 医学用語解説「相分離・相転移」、炎症と免疫 28(4)
  • 二宮賢介、廣瀬哲郎 細胞内の相分離構造体形成を主導するRNAの役割、化学工業「注目される最先端相分離研究」
  • 廣瀬哲郎 ゲノムの暗黒物質ノンコーディングRNAの機能探索、生産と技術 72(4): 56-58

2019年

  • 高桑央、山崎智弘、廣瀬哲郎 ノンコーディングRNAにより誘導される核内構造体形成機構、実験医学 37: 1398-1404
  • 山崎智弘、廣瀬哲郎 lncRNAの機能と関連疾患について、医学のあゆみ 269(5)
  • 廣瀬哲郎 細胞内構造を支配するncRNA、医学のあゆみ 269(4): 277-282
  • 廣瀬哲郎 ノンコーディングRNAによる相転移を介した核内構造構築機構、科研費NEWS 2: 15

2018年

  • 山崎智弘、廣瀬哲郎 長鎖非コードRNAであるNEAT1の機能ドメインは相分離を介して核内構造体であるパラスペックルの形成をひき起こす、ライフサイエンス新着論文レビュー
  • 廣瀬哲郎、中川真一 超解像顕微鏡で長鎖ncRNAの機能解析、日経バイオテク (2018.7.23) : 50-53

2017年

  • 廣瀬哲郎 Joan A. SteitzーRNAバイオロジーのひたむきな先導者、実験医学 35: 3299-3301

2016年

  • 中條岳志、廣瀬哲郎 核内ボディの骨格として働く構造構築RNA (arcRNA) ノンコーディングRNA〜RNA分子の全体像を俯瞰する〜廣瀬哲郎・泊幸秀編、化学同人: 259-270

2015年

  • 二宮賢介、廣瀬哲郎 ヒートショック誘導性lncRNAと核内構造体、実験医学 33: 3290-3291
  • 山崎智弘、廣瀬哲郎 パラスペックル-NEAT1 lncRNAをコアとする核内構造体、実験医学 33: 3292-3293
  • 川口哲哉、廣瀬哲郎、中川真一 簡単RNA 蛍光 in situハイブリダイゼーション実験、実験医学 33: 2283-2288

2014年

  • 廣瀬哲郎 長鎖ノンコーディングRNAと疾患、北海道医学誌 89: 163-164
  • 廣瀬哲郎 ゲノムの暗黒物質の体系的理解に向けて(未来をつなぐ風)、実験医学 32: 2658
  • 廣瀬哲郎、谷川明恵 NEAT1長鎖ノンコーディングRNAは、タンパク質の核内構造体への係留を介して転写を制御する、実験医学 32: 1249-1252

2013年

  • 萬年太郎、廣瀬哲郎 ノンコーディングRNAによる核内構造体構築機構、実験医学 31: 1157-1164

2012年

  • 中條岳志、廣瀬哲郎 長鎖非コードRNAと疾患、細胞 44: 585-588
  • 廣瀬哲郎 相反する制御機能を担う機能性RNAを発見、産総研TODAY 10: 15

2011年

  • 廣瀬哲郎 長鎖非コードRNAの性状と疾患への関与、臨床検査 55: 900-905
  • 廣瀬哲郎 非コードRNAの新しい制御機能と疾患への関わり、医学のあゆみ 238: 400-406
  • 長沼孝雄、廣瀬哲郎 核内構造体形成を司る長鎖ncRNA、実験医学 29: 1736-1742

2010年

  • 廣瀬哲郎 明らかになってきたエピゲノム制御におけるRNAの役割、医学のあゆみ 235: 1013-1018
  • 廣瀬哲郎 non-coding RNAから機能性RNAへ:医療応用への新たな展開、実験医学 28: 164-170
  • 長沼孝雄、廣瀬哲郎 ノンコーディングRNAの機能単位、実験医学 28: 30-36

2009年

  • 井手上賢、廣瀬哲郎 核内局在RNAの簡便で効率の良いノックダウン法、実験医学 28: 97-101
  • 北尾紗織、廣瀬哲郎 核内のRNA顆粒構造とその生理機能、蛋白質核酸酵素 54: 2127-2132
  • 日野公洋、廣瀬哲郎 snoRNAによる選択的スプライシングの調節、蛋白質核酸酵素 54: 2049-2054
  • 廣瀬哲郎 機能不明の細胞核内RNAを個別に分解する方法を開発、産総研TODAY 9: 12
  • 日野公洋、廣瀬哲郎 snoRNA異常疾患、遺伝子医学MOOK 15号「最新RNAと疾患研究」: 85-90
  • 日野公洋、廣瀬哲郎 snoRNAの機能異常による疾患、Bio Clinica 24: 46-51
  • 佐々木保典、廣瀬哲郎 「かたち」を生み出すRNA:機能構築RNAの研究から創薬へ、JITAニュースレター 21: 2-3
  • 佐々木保典、廣瀬哲郎 ncRNAを特徴付ける細胞内挙動と機能、細胞工学 28: 138-141
  • 廣瀬哲郎 眠りから覚めたRNA -基礎の基礎-、細胞工学 28: 110-115

2008年

  • 廣瀬哲郎 ノンコーディングRNA機能へのアプローチ法、蛋白質核酸酵素 53: 1940-1949
  • 廣瀬哲郎 名前のないRNAと共に、病態代謝研究会40周年記念誌: 98

2007年

  • 廣瀬哲郎 ncRNAの機能解析とヒトの疾患へのアプローチ、Medical Bio 4: 41-44

2006年

  • 佐々木保典、廣瀬哲郎 snoRNAの生合成と機能に関する新知見、蛋白質核酸酵素 51: 2437-2442
  • 井手上賢、廣瀬哲郎 RNAプロセシングを監視する核内RNA品質管理機構、蛋白質核酸酵素 51: 2205-2209
  • 廣瀬哲郎、塩見美喜子 機能性RNAの基本的な特徴と機能、ゲノム医学 6: 97-101

2005年

  • 廣瀬哲郎 RNAプロセシングの進行を規定するRNPリモデリング、実験医学 23: 1896-1901

2004年

  • 廣瀬哲郎 RNAの転写後修飾に必要なsnoRNAのユニークな生合成機構、実験医学「RNA研究の新展開」22: 71-76
  • 廣瀬哲郎 イントロンから生み出されるsnoRNAの発現戦略と新たな機能、ゲノム医学 4: 29-34
  • 廣瀬哲郎 イントロンを介した遺伝子発現の協調機構、蛋白質核酸酵素 49: 1288-1295

2003年以前

  • 廣瀬哲郎、Steitz JA. リボソームRNA修飾を司るsnoRNPの構造と機能、細胞工学 22: 960-964, 2003
  • 杉田護、廣瀬哲郎、杉浦昌弘 葉緑体遺伝子発現における転写後制御、蛋白質核酸酵素 45: 132-138, 2000
  • 廣瀬哲郎 葉緑体のRNAエディティング、「RNA研究の最前線」(志村令郎、渡辺公綱共編) シュプリンガー・フェアラーク東京: 206-209, 2000
  • 廣瀬哲郎、杉浦昌弘 翻訳過程における葉緑体遺伝子の発現制御機構、日本農芸化学会誌 71: 42-44, 1997